Regulation of Wnt signaling by protocadherins

Semin Cell Dev Biol. 2017 Sep:69:158-171. doi: 10.1016/j.semcdb.2017.07.043. Epub 2017 Aug 1.


The ∼70 protocadherins comprise the largest group within the cadherin superfamily. Their diversity, the complexity of the mechanisms through which their genes are regulated, and their many critical functions in nervous system development have engendered a growing interest in elucidating the intracellular signaling pathways through which they act. Recently, multiple protocadherins across several subfamilies have been implicated as modulators of Wnt signaling pathways, and through this as potential tumor suppressors. Here, we review the extant data on the regulation by protocadherins of Wnt signaling pathways and components, and highlight some key unanswered questions that could shape future research.

Keywords: Cancer; Cell adhesion; Epigeneticsextracellular cadherin (EC); Planar cell polarity; Tumor suppressor.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cadherins / genetics
  • Cadherins / metabolism*
  • Gene Expression Regulation
  • Humans
  • Models, Biological
  • Wnt Signaling Pathway*


  • Cadherins