A controlled assessment of propranolol in the treatment of neuroleptic-induced akathisia

Br J Psychiatry. 1986 Jul:149:42-5. doi: 10.1192/bjp.149.1.42.


Twelve patients with neuroleptic-induced akathisia were treated in a randomised, double-blind, cross-over design with propranolol and matching placebo. Propranolol caused significant decrements in both subjective and objective ratings of akathisia, but not in anxiety scores. This confirms prior findings of the efficacy of propranolol in akathisia induced by neuroleptic treatment.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Akathisia, Drug-Induced*
  • Antipsychotic Agents / adverse effects*
  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Propranolol / therapeutic use*
  • Psychomotor Agitation / drug therapy
  • Random Allocation
  • Schizophrenia / drug therapy


  • Antipsychotic Agents
  • Propranolol