Role of Polyethylene Glycol in the Treatment of Functional Constipation in Children

J Pediatr Gastroenterol Nutr. 2017 Oct;65(4):361-363. doi: 10.1097/MPG.0000000000001704.


According to international guidelines, polyethylene glycol (PEG) is the laxative of first choice in the treatment of functional constipation in children, both for disimpaction and for maintenance treatment. PEG acts as an osmotic laxative and its efficacy is dose dependent. PEG is highly effective, has a good safety profile, and is well tolerated by children. Only minor adverse events have been reported. Overall the use of PEG in children has been reported to be safe, although in patients predisposed to water and electrolyte imbalances monitoring of serum electrolytes should be considered.

Publication types

  • Review

MeSH terms

  • Child
  • Constipation / drug therapy*
  • Contraindications, Drug
  • Drug Compounding
  • Drug Dosage Calculations
  • Humans
  • Laxatives / adverse effects
  • Laxatives / therapeutic use*
  • Polyethylene Glycols / adverse effects
  • Polyethylene Glycols / therapeutic use*
  • Treatment Outcome


  • Laxatives
  • Polyethylene Glycols