Molecular structure of human lymphocyte receptor for immunoglobulin E

Cell. 1986 Dec 5;47(5):657-65. doi: 10.1016/0092-8674(86)90508-8.


We have isolated and sequenced a cDNA clone encoding the human lymphocyte receptor for IgE (Fc epsilon R). The deduced protein sequence reveals that Fc epsilon R consists of 321 amino acids, without any signal sequence, and is oriented with its N-terminus on the cytoplasmic side and its C-terminus on the outside of the cell. This molecule shows striking sequence homology with chicken asialoglycoprotein receptor (hepatic lectin), suggesting a possible role for Fc epsilon R in endocytosis. Fc epsilon R mRNA is expressed in B cells, B cell lines, and macrophage cell lines. It is not expressed in T cells or T cell lines, with the exception of an HTLV-transformed T cell line. mRNAs expressed in a macrophage line and in the latter T cell line differ in size from mRNA expressed in B cells. Human BSF-1 (or IL-4) induces the expression of Fc epsilon R mRNA in B cells, but not in T cells.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Asialoglycoprotein Receptor
  • B-Lymphocytes / immunology*
  • Base Sequence
  • Chickens / genetics
  • DNA / genetics
  • Humans
  • L Cells / analysis
  • Mice
  • Poly A / genetics
  • RNA, Messenger / genetics
  • Receptors, Fc / genetics*
  • Receptors, IgE
  • Receptors, Immunologic / genetics*
  • Sequence Homology, Nucleic Acid


  • Asialoglycoprotein Receptor
  • RNA, Messenger
  • Receptors, Fc
  • Receptors, IgE
  • Receptors, Immunologic
  • Poly A
  • DNA

Associated data

  • GENBANK/M14766