Engineering Skin with Skinny Genes

Anika Böttcher; Heiko Lickert; Matthias Tschöp

doi:10.1016/j.stem.2017.07.013

Engineering Skin with Skinny Genes

Cell Stem Cell. 2017 Aug 3;21(2):153-155. doi: 10.1016/j.stem.2017.07.013.

Authors

Anika Böttcher¹, Heiko Lickert², Matthias Tschöp³

Affiliations

¹ Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Center Munich, Am Parkring 11, 85748 Garching, Germany.
² Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Center Munich, Am Parkring 11, 85748 Garching, Germany; Technische Universität München, Ismaninger Strasse 22, 81675 München, Germany. Electronic address: heiko.lickert@helmholtz-muenchen.de.
³ Institute of Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Center Munich, Am Parkring 13, 85748 Garching, Germany; Division of Metabolic Diseases, Technische Universität München, Ismaninger Strasse 22, 81675 München, Germany. Electronic address: tschop@helmholtz-muenchen.de.

PMID: 28777938
DOI: 10.1016/j.stem.2017.07.013

Abstract

The increasing prevalence of obesity and diabetes is an urgent worldwide health challenge. Now in Cell Stem Cell, Yue et al. (2017) report a proof-of-concept study using genetically engineered skin transplants that produce the incretin GLP-1 to prevent diet-induced obesity, suggesting a powerful approach for treating metabolic disorders.

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MeSH terms

Diabetes Mellitus, Type 2*
Diet
Humans
Incretins
Obesity
Stem Cells

Substances

Incretins