Tumor necrosis factor-alpha -863C/A polymorphism is associated with Guillain-Barré syndrome in Bangladesh

J Neuroimmunol. 2017 Sep 15:310:46-50. doi: 10.1016/j.jneuroim.2017.06.005. Epub 2017 Jun 20.

Abstract

Guillain-Barré syndrome (GBS) is a post-infectious autoimmune polyneuropathy regulated by pro- and anti-inflammatory cytokines; TNFA polymorphisms may exert immune pathogenic roles in GBS. We assessed TNFA promoter region polymorphisms (-238G/A, -308G/A, -857C/T, -863C/A) in Bangladeshi patients with GBS (n=300) and healthy controls (n=300) by PCR-RFLP and ASO-PCR. TNFA -863CA was significantly associated with GBS disease susceptibility (P=0.0154) and disease severity (P=0.0492). TNFA -238A allele was more frequent among anti-ganglioside (GM1) antibody-positive patients (P=0.0092) and -863AA associated with AMAN subtype of GBS (P=0.0398). TNFA -863C/A may contribute to GBS severity and pathogenesis in Bangladeshi patients.

Keywords: Allele; Genotype; Guillain-Barré syndrome; Promoter region; SNPs; TNFA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antibodies / blood
  • Bangladesh / epidemiology
  • Child
  • Child, Preschool
  • Female
  • Gangliosides / immunology
  • Genetic Association Studies
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Guillain-Barre Syndrome / genetics*
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics*
  • Tumor Necrosis Factor-alpha / genetics*
  • Young Adult

Substances

  • Antibodies
  • Gangliosides
  • Tumor Necrosis Factor-alpha