Vulvar Neoplasms, Benign and Malignant

Obstet Gynecol Clin North Am. 2017 Sep;44(3):339-352. doi: 10.1016/j.ogc.2017.04.002.


Cutaneous vulvar neoplasms are commonly encountered at gynecology visits, with 2% of women having a benign vulvar melanocytic nevus and 10% to 12% of nevi being vulvar. High-grade squamous intraepithelial lesions (vulvar intraepithelial neoplasia 2 or 3) occurs in 5 per 100,000 women, with increasing incidence in the past 30 years. The recognition of these lesions and differentiation between benign, premalignant, and malignant stages are crucial for adequate diagnosis, clinical monitoring, and treatment. The presentation, diagnosis, and management of benign and malignant vulvar proliferations are discussed with focus on practical aspects of clinical care.

Keywords: Basal cell carcinoma; Differentiated vulvar intraepithelial neoplasia (dVIN); Genital nevi; High-grade squamous intraepithelial lesion (HSIL); Melanosis; Paget disease; Squamous cell carcinoma (SCC); Vulvar melanoma.

Publication types

  • Review

MeSH terms

  • Female
  • Humans
  • Precancerous Conditions / diagnosis
  • Precancerous Conditions / pathology*
  • Vulva / pathology*
  • Vulvar Neoplasms / diagnosis
  • Vulvar Neoplasms / pathology*