TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections

Biochimie. 2017 Nov;142:1-10. doi: 10.1016/j.biochi.2017.07.016. Epub 2017 Aug 1.


Influenza virus and coronavirus epidemics or pandemics have occurred in succession worldwide throughout the early 21st century. These epidemics or pandemics pose a major threat to human health. Here, we outline a critical role of the host cell protease TMPRSS2 in influenza virus and coronavirus infections and highlight an antiviral therapeutic strategy targeting TMPRSS2.

Keywords: Coronavirus; Influenza virus; TMPRSS2; Therapeutics.

Publication types

  • Review

MeSH terms

  • Animals
  • Coronavirus Infections / drug therapy*
  • Coronavirus Infections / enzymology*
  • Humans
  • Influenza, Human / drug therapy*
  • Influenza, Human / enzymology*
  • Molecular Targeted Therapy / methods*
  • Serine Endopeptidases / metabolism*
  • Virus Replication / drug effects


  • Serine Endopeptidases
  • serine endopeptidase