Hypoxia-inducible-factor-1 in trauma and critical care

J Crit Care. 2017 Dec;42:207-212. doi: 10.1016/j.jcrc.2017.07.029. Epub 2017 Jul 12.


HIF-1 is a ubiquitous signaling molecule constantly expressed by the body, but is degraded during normoxic conditions. In hypoxic conditions, it persists and is active. Hypoxia is often associated with trauma due to interrupted blood flow, inflammation or other reasons, causing HIF-1 to be active in signaling and recovery. In this review, the function of HIF-1 is examined, as well as its clinical significance with regard to trauma and critical care. Using this information, we then identify potential points of treatment and intervention.

Keywords: HIF-1; Hypoxia; Inflammation; Ischemia; Sepsis.

Publication types

  • Review

MeSH terms

  • Acute Lung Injury / complications
  • Brain Injuries, Traumatic / complications
  • Critical Care
  • Humans
  • Hypoxia / diagnosis
  • Hypoxia / physiopathology*
  • Hypoxia / therapy
  • Hypoxia-Inducible Factor 1 / metabolism
  • Hypoxia-Inducible Factor 1 / physiology*
  • Inflammation / complications
  • Liver / injuries
  • Up-Regulation / physiology
  • Wounds and Injuries / complications*


  • Hypoxia-Inducible Factor 1