Repurposing Drugs in Oncology: Next Steps

Ciska Verbaanderd; Lydie Meheus; Isabelle Huys; Pan Pantziarka

doi:10.1016/j.trecan.2017.06.007

Repurposing Drugs in Oncology: Next Steps

Trends Cancer. 2017 Aug;3(8):543-546. doi: 10.1016/j.trecan.2017.06.007. Epub 2017 Jul 12.

Authors

Ciska Verbaanderd¹, Lydie Meheus², Isabelle Huys³, Pan Pantziarka⁴

Affiliations

¹ Anticancer Fund, Brussels, 1853 Strombeek-Bever, Belgium; Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium.
² Anticancer Fund, Brussels, 1853 Strombeek-Bever, Belgium.
³ Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium.
⁴ Anticancer Fund, Brussels, 1853 Strombeek-Bever, Belgium; The George Pantziarka TP53 Trust, London KT1 2JP, UK. Electronic address: pan.pantziarka@anticancerfund.org.

PMID: 28780930
DOI: 10.1016/j.trecan.2017.06.007

Abstract

The repurposing of existing non-cancer drugs is a potential source of new treatment options for cancer patients with high unmet medical needs. While scientific research is progressing rapidly in the field of drug repurposing, the implementation of drug repurposing still faces important financial and regulatory hurdles that should be addressed to optimise clinical adoption.

Keywords: drug repositioning; drug repurposing; health systems; neoplasms; policy.

MeSH terms

Antineoplastic Agents / economics
Antineoplastic Agents / therapeutic use*
Drug Approval
Drug Discovery / methods
Drug Discovery / trends
Drug Industry / economics*
Drug Industry / legislation & jurisprudence
Drug Repositioning / economics
Drug Repositioning / methods*
Drug Repositioning / trends
Drugs, Generic / economics
Drugs, Generic / therapeutic use
Humans
Medical Oncology / economics
Medical Oncology / legislation & jurisprudence
Medical Oncology / methods*
Medical Oncology / trends
Neoplasms / drug therapy*

Substances

Antineoplastic Agents
Drugs, Generic