Skin microneedling plus platelet-rich plasma versus skin microneedling alone in the treatment of atrophic post acne scars: a split face comparative study

J Dermatolog Treat. 2018 May;29(3):281-286. doi: 10.1080/09546634.2017.1365111. Epub 2017 Sep 26.


Introduction: Acne scarring is a permanent disfiguring sequel, which can take varied morphological forms. Many therapeutic measures have been performed to improve acne scarring such as microneedling. Our objective is to evaluate the efficacy and safety of microneedling alone versus microneedling combined with platelet rich plasma in the treatment of post acne.

Methods: The study included 35 patients with mild to severe post acne atrophic scar. All the patients received four sequential treatments of skin microneedling alone on the right side of the face and skin microneedling followed by topical application of platelet rich plasma (PRP) on the left side of the face with an interval of 3 weeks. Two blinded dermatologists evaluated the clinical response according to qualitative global acne scarring system grading of Goodman & Baron. Patients are queried about their satisfaction with the treatment outcomes.

Results: The study included 35 patients with a mean age of 24.7 ± 6.8 years. There was a significant improvement in the degree of scar severity before and after treatment on both the sides. Regarding patient's satisfaction grades, there was a significant improvement after both treatment modalities with insignificant differences between both treatment modalities.

Conclusions: Both microneedling and microneedling in combined with PRP showed satisfactory results.

Keywords: Microneedling; PRP; scar.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Acne Vulgaris / complications*
  • Adolescent
  • Adult
  • Cicatrix / etiology
  • Cicatrix / pathology
  • Cicatrix / therapy*
  • Cosmetic Techniques*
  • Female
  • Humans
  • Male
  • Needles*
  • Patient Satisfaction
  • Platelet-Rich Plasma / chemistry*
  • Prospective Studies
  • Severity of Illness Index
  • Skin / pathology
  • Treatment Outcome
  • Young Adult