Existence of antiopiate systems as illustrated by MIF-1/Tyr-MIF-1

Life Sci. 1986 Dec 8;39(23):2153-9. doi: 10.1016/0024-3205(86)90391-7.


Evidence is presented that the small peptides MIF-1/Tyr-MIF-1 are part of an endogenous antiopiate system that may function to balance the opiate system. We review the biological activity, behavioral activity, and functional effects of this proposed opiate antagonist system. In addition, we suggest, based on antinociceptive mechanisms, that the individual components of the antiopiate system might function differently from naloxone.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Analgesia
  • Animals
  • Behavior, Animal / drug effects
  • Dose-Response Relationship, Drug
  • Hypothalamus / metabolism
  • Kinetics
  • MSH Release-Inhibiting Hormone / analogs & derivatives*
  • MSH Release-Inhibiting Hormone / physiology*
  • Naloxone / pharmacology
  • Narcotic Antagonists*
  • Receptors, Opioid / metabolism


  • Narcotic Antagonists
  • Receptors, Opioid
  • Naloxone
  • tyrosyl-prolyl-leucyl-glycinamide
  • MSH Release-Inhibiting Hormone