Neutrophilic Inflammation in Asthma and Association with Disease Severity

Trends Immunol. 2017 Dec;38(12):942-954. doi: 10.1016/ Epub 2017 Aug 4.


Asthma is a chronic inflammatory disorder of the airways. While the local infiltration of eosinophils and mast cells, and their role in the disease have long been recognized, neutrophil infiltration has also been assessed in many clinical studies. In these studies, airway neutrophilia was associated with asthma severity. Importantly, neutrophilia also correlates with asthma that is refractory to corticosteroids, the mainstay of asthma treatment. However, it is now increasingly recognized that neutrophils are a heterogeneous population, and a more precise phenotyping of these cells may help delineate different subtypes of asthma. Here, we review current knowledge of the role of neutrophils in asthma and highlight future avenues of research in this field.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Animals
  • Asthma / drug therapy
  • Asthma / immunology*
  • Cell Movement
  • Disease Progression
  • Drug Resistance
  • Humans
  • Inflammation / immunology*
  • Neutrophil Infiltration*
  • Neutrophils / immunology*
  • Phenotype
  • Respiratory System / immunology*


  • Adrenal Cortex Hormones