Hope for CKD-MBD Patients: New Diagnostic Approaches for Better Treatment of CKD-MBD

Kidney Dis (Basel). 2017 Jul;3(1):8-14. doi: 10.1159/000477244. Epub 2017 Jun 16.

Abstract

Background: Chronic kidney disease-mineral and bone disorder (CKD-MBD) patients have a huge morbidity and mortality. Only relatively minor progress in therapeutic strategies has been made in the past decades. This is at least partially due to a lack of predictive diagnostic tools allowing personalized treatment of CKD-MBD patients.

Summary: In this review we describe recent progress in the diagnosis of disturbances of calcium and phosphate metabolism in patients with CKD-MBD, measuring biological active nonoxidized parathyroid hormone as well as the overall likelihood of a patient to get calcified.

Key message: There is hope. The new tools have the potential of allowing personalized therapy for the treatment of CKD-MBD and hence improving outcome.

Keywords: Biomarker; Calcification propensity; Chronic kidney disease-mineral and bone disorder; Morbidity; Mortality; Nonoxidized parathyroid hormone; T50 test.

Publication types

  • Review