Abstract
Known diketopiperazine WIN 64821 and its asymmetric stereoisomers (1-3) had been isolated from the culture broth of a marine gut fungus Aspergillus sp. DX4H. The planar and stereochemistry for new compounds were determined by a suite of techniques including mass, NMR and CD spectra together with Marfey's method. Their inhibitory activity against PC3 cell line had been tested.
Keywords:
Aspergillus; Bispyrrolidinoindoline diketopiperazine; asymmetric; cytotoxicity; identification.
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Aquatic Organisms
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Aspergillus / chemistry*
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Aspergillus / genetics
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Cell Line, Tumor
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Circular Dichroism
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Drug Screening Assays, Antitumor
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Fermentation
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Humans
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Indoles / chemistry*
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Indoles / isolation & purification
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Indoles / pharmacology*
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Magnetic Resonance Spectroscopy
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Male
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Molecular Structure
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Piperazines / chemistry*
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Piperazines / isolation & purification
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Piperazines / pharmacology*
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Prostatic Neoplasms / drug therapy
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Prostatic Neoplasms / pathology
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Spectrometry, Mass, Electrospray Ionization
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Stereoisomerism
Substances
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Antineoplastic Agents
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Indoles
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Piperazines
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WIN 64821