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Comment
. 2017 Aug 7;42(3):205-207.
doi: 10.1016/j.devcel.2017.07.015.

Midkine and Melanoma Metastasis: A Malevolent Mix

Sinem Karaman  1 , Kari Alitalo  2
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Comment

Midkine and Melanoma Metastasis: A Malevolent Mix

Sinem Karaman et al. Dev Cell. .
Free article

Abstract

Using an in vivo reporter for lymphangiogenesis, a recent study in Nature from Olmeda et al. (2017) describes a new subset of melanomas that induce systemic pre-conditioning of distant organs for formation of tumor metastatic niches, and identifies the responsible factor as the pleiotropic cytokine midkine.

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  • Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine.
    Olmeda D, Cerezo-Wallis D, Riveiro-Falkenbach E, Pennacchi PC, Contreras-Alcalde M, Ibarz N, Cifdaloz M, Catena X, Calvo TG, Cañón E, Alonso-Curbelo D, Suarez J, Osterloh L, Graña O, Mulero F, Megías D, Cañamero M, Martínez-Torrecuadrada JL, Mondal C, Di Martino J, Lora D, Martinez-Corral I, Bravo-Cordero JJ, Muñoz J, Puig S, Ortiz-Romero P, Rodriguez-Peralto JL, Ortega S, Soengas MS. Olmeda D, et al. Nature. 2017 Jun 28;546(7660):676-680. doi: 10.1038/nature22977. Nature. 2017. PMID: 28658220 Free PMC article.

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