(-)-Propranolol blocks the inhibition of serotonergic dorsal raphe cell firing by 5-HT1A selective agonists

Eur J Pharmacol. 1986 Sep 9;128(3):295-8. doi: 10.1016/0014-2999(86)90782-x.


The ability of the beta-adrenoceptor antagonist propranolol to block the effects of serotonin (5-HT) and 5-HT1A-selective agonists on the spontaneous firing of serotonergic dorsal raphe neurons was assessed. During microiontophoretic application, (-)- but not (+)-propranolol rapidly and reversibly blocked the suppressant effects of the 5-HT1A-selective agonists ipsapirone (TVX Q 7821) and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). However, (-)-propranolol was a relatively weak antagonist of 5-HT itself, suggesting that the endogenous neurotransmitter may have actions on dorsal raphe neurons in addition to those mediated by 5-HT1A receptors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 8-Hydroxy-2-(di-n-propylamino)tetralin
  • Animals
  • Anti-Anxiety Agents / pharmacology
  • In Vitro Techniques
  • Iontophoresis
  • Male
  • Propranolol / pharmacology*
  • Pyrimidines / pharmacology
  • Raphe Nuclei / drug effects*
  • Rats
  • Rats, Inbred Strains
  • Receptors, Serotonin / drug effects*
  • Stereoisomerism
  • Tetrahydronaphthalenes / pharmacology


  • Anti-Anxiety Agents
  • Pyrimidines
  • Receptors, Serotonin
  • Tetrahydronaphthalenes
  • ipsapirone
  • 8-Hydroxy-2-(di-n-propylamino)tetralin
  • Propranolol