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Case Reports
, 71 (2), 144-147

Genetic Counseling and Prenatal Diagnosis of Triploidy During the Second Trimester of Pregnancy

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Case Reports

Genetic Counseling and Prenatal Diagnosis of Triploidy During the Second Trimester of Pregnancy

Milenko Kolarski et al. Med Arch.

Abstract

Introduction: Triploidy is a lethal chromosomal numeric abnormality, characterized on extra haploid set of chromosomes. It occurs in 2 to 3% of conceptuses and accounts for approximately 20% of chromosomally abnormal first-trimester miscarriages. As such, triploidy is estimated to occur in 1 of 3,500 pregnancies at 12 weeks', 1 in 30,000 at 16 weeks', and 1 in 250,000 at 20 weeks' gestation.

Case report: We present a case of second-trimester triploidy diagnosed prenataly at our center. 28-years-old gravida with a first spontaneous pregnancy had early gestational hypertension. Ultrasound examination in 146/7 weeks' gestation revealed asymmetric intrauterine growth retardation. We recommended biochemical maternal serum screening during second trimester of pregnancy (AFP, HCG, uE3). Result of biochemical screening was indication for cytogenetic analysis from amniotic fluid cells and we recommended early amniocentesis in 156/7 weeks' gestation. Result showed abnormal karyotype of the fetus (69,XXX triploidy), and DNA analysis confirmed Type-2 Diginy. Parents decided to terminate this pregnancy, and it was done at 22 weeks' gestation.

Conclusion: We emphasize the importance of non-invasive prenatal exminationes-biochemical serum screening during second trimester of pregnancy, and ultrasound examinations in prenatal screening of syndroma Down and other chromosomal abnormalities.

Keywords: 69,XXX; Prenatal diagnostics; biochemical screening; early amniocentesis; triploidy.

Conflict of interest statement

• Conflict of interest: none declared.

Figures

Figure 1
Figure 1
Ultrasoud examination: asimetric IUGR of the fetus and micrognatio
Figure 2
Figure 2
Ultrasound examination: gestational age 116/7 gw; Fl/AC 0.30; asimetric IUGR (3 weeks); normal ultrasound morfology of placental tissue and amniotic fluid
Figure 3
Figure 3
Karyotype of the fetus: Poliploidy-triploidy 69,XXX (karyotype from amniotic fluid)
Figure 4
Figure 4
PCR - DNA analysis: Triploidy 69, XXX, Type-2 (Diginy)

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