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. 2017 Jul;73(3):261-266.
doi: 10.1016/j.mjafi.2017.01.005. Epub 2017 Feb 16.

A Clinical Correlation of Conjunctival Microangiopathy With Grades of Retinopathy in Type 2 Diabetes Mellitus

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A Clinical Correlation of Conjunctival Microangiopathy With Grades of Retinopathy in Type 2 Diabetes Mellitus

M A Khan et al. Med J Armed Forces India. .
Free PMC article

Abstract

Background: Conjunctival microangiopathy has been described among diabetics similar to retinal vessel angiopathy. Correlation of these conjunctival microangiopathy changes with retinopathy may form the basis of screening by external examination without expert fundus evaluation.

Methods: Conjunctival vessels widths and tortuous segment length of conjunctival vessels of 96 patients with type 2 diabetes mellitus were photographed and measured by the Zeiss Fundus camera Visupac software. The measurements were correlated with retinopathy grade in those eyes.

Results: The mean conjunctival vessel width was 40.61 μ (SD 17.25) with a uniform increase from 34.4 μ (SD 8.70) in mild NPDR to 53.50 μ (SD 33.45) in the PDR group which was statistically significant (p < 0.01). The tortuous conjunctival vessel segment length increased from 711.51 μ (SD 83.90) in the mild NPDR group to 921.94 μ (SD 129.26) in those with PDR (p < 0.01). Vessel width greater than 80 μ was seen only in PDR and tortuosity values greater than 900 μ were seen in severe grades (severe NPDR and PDR). Both conjunctival vessel width and tortuosity showed a positive statistical correlation with increasing severity of retinopathy (r = 0.386, r2 = 0.149 and r = 0.645, r2 = 0.415).

Conclusion: A positive correlation was seen between conjunctival vessel width and tortuosity with severity of retinopathy. Widths over 80 μ and tortuous segment length over 900 μ are suggestive of severe grades of retinopathy.

Keywords: Conjunctival microangiopathy; Diabetes; Retinopathy.

Figures

Fig. 1
Fig. 1
(a) Screen shot of the measure function keys used to measure the width of vessel and tortuous segment length. (b) Dilated and tortuous conjunctival vessel in a case of PDR.
Fig. 2
Fig. 2
Graph showing correlation of width of conjunctival vessel with severity of retinopathy.
Fig. 3
Fig. 3
Graph showing correlation of tortuosity of conjunctival vessel with severity of retinopathy.

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