Abstract
Hormone binding and localization of the c-erb-A protein suggest that it is a receptor for thyroid hormone, a nuclear protein that binds to DNA and activates transcription. In contrast, the product of the viral oncogene v-erb-A is defective in binding the hormone but is still located in the nucleus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Cloning, Molecular
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DNA / metabolism
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Genes*
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Humans
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogene Proteins / metabolism
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Proto-Oncogenes*
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Receptors, Thyroid Hormone / genetics*
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Retroviridae / genetics
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Triiodothyronine / metabolism
Substances
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Proto-Oncogene Proteins
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Receptors, Thyroid Hormone
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Triiodothyronine
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DNA