The c-erb-A protein is a high-affinity receptor for thyroid hormone

Nature. 1986 Dec 18-31;324(6098):635-40. doi: 10.1038/324635a0.

Abstract

Hormone binding and localization of the c-erb-A protein suggest that it is a receptor for thyroid hormone, a nuclear protein that binds to DNA and activates transcription. In contrast, the product of the viral oncogene v-erb-A is defective in binding the hormone but is still located in the nucleus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA / metabolism
  • Genes*
  • Humans
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogenes*
  • Receptors, Thyroid Hormone / genetics*
  • Retroviridae / genetics
  • Triiodothyronine / metabolism

Substances

  • Proto-Oncogene Proteins
  • Receptors, Thyroid Hormone
  • Triiodothyronine
  • DNA

Associated data

  • GENBANK/Y00987