The c-erb-A gene encodes a thyroid hormone receptor

Nature. 1986 Dec 18-31;324(6098):641-6. doi: 10.1038/324641a0.

Abstract

The cDNA sequence of human c-erb-A, the cellular counterpart of the viral oncogene v-erb-A, indicates that the protein encoded by the gene is related to the steroid hormone receptors. Binding studies with the protein show it to be a receptor for thyroid hormones.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Binding, Competitive
  • Cell Transformation, Neoplastic
  • DNA / analysis
  • Genes*
  • Humans
  • Kinetics
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins / immunology
  • Proto-Oncogenes*
  • Receptors, Thyroid Hormone / genetics*
  • Receptors, Thyroid Hormone / metabolism

Substances

  • Proto-Oncogene Proteins
  • Receptors, Thyroid Hormone
  • DNA

Associated data

  • GENBANK/X04707