Anxiolytic activity of an endogenous adrenal steroid

Brain Res. 1986 Nov 29;398(2):382-5. doi: 10.1016/0006-8993(86)91500-3.


The A-ring reduced metabolite of deoxycorticosterone, 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone (THDOC) was recently shown to act at the gamma-aminobutyric acid receptor-chloride ion channel complex in rat brain. The behavioral profile of THDOC was investigated using two animal models of anxiety, the two-chambered mouse exploration test and the lick suppression conflict test. THDOC showed anxiolytic activity in both animal models, with an anxiolytic dose range, 5-15 mg/kg i.p., separable from the sedative dose range, above 20-30 mg/kg i.p.

MeSH terms

  • Animals
  • Anti-Anxiety Agents*
  • Conflict, Psychological
  • Desoxycorticosterone / analogs & derivatives*
  • Desoxycorticosterone / pharmacology
  • Drug Evaluation, Preclinical
  • Exploratory Behavior / drug effects
  • Male
  • Mice


  • Anti-Anxiety Agents
  • Desoxycorticosterone
  • tetrahydrodeoxycorticosterone