Stimulation of hypothalamic beta-endorphin and dynorphin release by corticotropin-releasing factor (in vitro)

Brain Res. 1986 Dec 3;399(1):152-5. doi: 10.1016/0006-8993(86)90610-4.

Abstract

Corticotropin-releasing factor (CRF) at doses of 10(-12)-10(-8) M significantly stimulated the release of beta-endorphin and dynorphin from superfused rat hypothalamic slices. These effects were shown to be mediated by the CRF receptor since they were antagonized by the CRF receptor antagonist alpha-helical CRF9-41 (10(-6) M). The two opioid peptides showed different time courses of response and in the case of beta-endorphin, an attenuation of the response upon continued exposure to CRF was observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Corticotropin-Releasing Hormone / pharmacology*
  • Dose-Response Relationship, Drug
  • Dynorphins / metabolism*
  • Endorphins / metabolism*
  • Hypothalamus / metabolism*
  • In Vitro Techniques
  • Male
  • Rats
  • beta-Endorphin

Substances

  • Endorphins
  • beta-Endorphin
  • Dynorphins
  • Corticotropin-Releasing Hormone