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. 2017 Aug 3;22(31):30589.
doi: 10.2807/1560-7917.ES.2017.22.31.30589.

Novel Plasmid-Mediated Colistin Resistance mcr-4 Gene in Salmonella and Escherichia Coli, Italy 2013, Spain and Belgium, 2015 to 2016

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Free PMC article

Novel Plasmid-Mediated Colistin Resistance mcr-4 Gene in Salmonella and Escherichia Coli, Italy 2013, Spain and Belgium, 2015 to 2016

Alessandra Carattoli et al. Euro Surveill. .
Free PMC article

Abstract

A novel mcr colistin resistance gene was identified in a strain of Salmonella enterica, monophasic variant of serovar Typhimurium (4,5,12:i:- ), isolated from a pig at slaughter in Italy in 2013, and in Escherichia coli strains collected during routine diagnostic of post-weaning diarrhoea in pigs from Spain and Belgium in 2015 and 2016. Immediate implementation of mcr-screening including this novel gene variant is required for Salmonella and E. coli from humans and food-producing animals in Europe.

Keywords: ColE; Salmonella; colistin; mcr.

Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Plasmid content of the Salmonella isolate from swine, Italy 2013 (n = 1) and its transformant 3445T and map of the pMCR plasmid carrying the mcr-4 gene
Figure 2
Figure 2
Phylogenetic analysis of the entire MCR-4 protein sequence

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