Novel Plasmid-Mediated Colistin Resistance mcr-4 Gene in Salmonella and Escherichia Coli, Italy 2013, Spain and Belgium, 2015 to 2016

Euro Surveill. 2017 Aug 3;22(31):30589. doi: 10.2807/1560-7917.ES.2017.22.31.30589.

Abstract

A novel mcr colistin resistance gene was identified in a strain of Salmonella enterica, monophasic variant of serovar Typhimurium (4,5,12:i:- ), isolated from a pig at slaughter in Italy in 2013, and in Escherichia coli strains collected during routine diagnostic of post-weaning diarrhoea in pigs from Spain and Belgium in 2015 and 2016. Immediate implementation of mcr-screening including this novel gene variant is required for Salmonella and E. coli from humans and food-producing animals in Europe.

Keywords: ColE; Salmonella; colistin; mcr.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics*
  • Belgium
  • Colistin / pharmacology*
  • Drug Resistance, Bacterial / genetics
  • Escherichia coli / drug effects*
  • Escherichia coli / genetics*
  • Escherichia coli / isolation & purification
  • Italy
  • Plasmids / genetics
  • Salmonella Infections, Animal
  • Salmonella typhimurium / drug effects*
  • Salmonella typhimurium / genetics*
  • Salmonella typhimurium / isolation & purification
  • Spain
  • Swine / microbiology*
  • Swine Diseases

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Colistin