Diagnosis and Management of Coccidioidomycosis

Clin Chest Med. 2017 Sep;38(3):417-433. doi: 10.1016/j.ccm.2017.04.005. Epub 2017 Jun 3.


Coccidioidomycosis is a leading cause of community-acquired pneumonia within its traditional endemic zone in the Southwestern United States and portions of Mexico and Central and South America. Its incidence has increased dramatically within the endemic region; its presence outside of the region, facilitated by a mobile society, is also now substantial. Although only a fraction of the incident disease progresses beyond subclinical illness, this proportion is large in absolute terms and causes substantial disease burden. Diagnosis often depends on serologic interpretation. Treatment has been revolutionized by azole therapy. Controversy remains regarding the decision to treat in less severe disease.

Keywords: Coccidioidomycosis; Diagnosis; Fungal infections; Treatment.

Publication types

  • Review

MeSH terms

  • Antifungal Agents / therapeutic use*
  • Coccidioidomycosis / diagnosis*
  • Coccidioidomycosis / pathology
  • Coccidioidomycosis / therapy*
  • Humans


  • Antifungal Agents