Cardiovascular effects of urotensin II in anesthetized and pithed rats

Gen Comp Endocrinol. 1986 Dec;64(3):435-9. doi: 10.1016/0016-6480(86)90080-8.


Gillichthys urotensin II (GUII; 1.5-150 nmol kg-1) reduced blood pressure in anesthetized rats, diastolic pressure being reduced to a greater extent than systolic. The effect was slow in onset (peak at 4-5 min) and longlasting (up to 60 min), and was accompanied by a reflex tachycardia. The hypotension was not blocked by propranolol or by mepyramine. In pithed rats, GUII (150 nmol kg-1) reduced the pressor responses to sympathetic nerve stimulation, noradrenaline, and Arg-vasopressin. Somatostatin (150 nmol kg-1) had no effect on the sympathetic pressor response but reduced heart rate. It is concluded that GUII is a vasodilator in the rat, an action not shared with somatostatin.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anesthesia
  • Animals
  • Arginine Vasopressin / pharmacology
  • Blood Pressure / drug effects*
  • Heart Rate / drug effects*
  • Male
  • Norepinephrine / pharmacology
  • Peptides / pharmacology*
  • Rats
  • Somatostatin / pharmacology
  • Time Factors
  • Urotensins / pharmacology*


  • Peptides
  • Urotensins
  • Arginine Vasopressin
  • Somatostatin
  • urotensin II
  • Norepinephrine