68Ga-DOTATATE PET/CT Can Be an Alternative Imaging Method in Insulinoma Patients

J Nucl Med Technol. 2017 Sep;45(3):198-200. doi: 10.2967/jnmt.117.192708. Epub 2017 Aug 10.


Insulinomas are the most common cause of hypoglycemia, resulting from endogenous hyperinsulinism. The diagnosis of insulinoma is established by demonstrating inappropriately high serum insulin concentrations during a spontaneous or induced episode of hypoglycemia. Most insulinomas are islet-cell tumors. They are often small (<2 cm), benign, and difficult to localize with current imaging techniques. Insulinomas can be detected using either noninvasive procedures (e.g., transabdominal ultrasonography, spiral CT, MRI, 111In-pentetreotide imaging, and 18F-l-dihydroxyphenylalanine PET) or invasive procedures (e.g., endoscopic ultrasonography) or a selective arterial calcium stimulation test with hepatic venous sampling. Methods: We performed 68Ga-DOTATATE PET/CT on 3 patients with insulinoma. Results: All patients' insulinomas were shown clearly with 68Ga-DOTATATE PET/CT. Conclusion:68Ga-DOTATATE PET/CT imaging may be a useful noninvasive imaging technique to localize insulinomas preoperatively.

Keywords: 68Ga-DOTATATE PET/CT; insulinoma; neuroendocrine tumor.

Publication types

  • Case Reports

MeSH terms

  • Feasibility Studies
  • Female
  • Humans
  • Insulinoma / diagnostic imaging*
  • Male
  • Middle Aged
  • Organometallic Compounds*
  • Pancreatic Neoplasms / diagnostic imaging*
  • Positron Emission Tomography Computed Tomography / methods*
  • Radiopharmaceuticals


  • Organometallic Compounds
  • Radiopharmaceuticals
  • gallium Ga 68 dotatate