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. 2017 Oct 18;18(20):2000-2006.
doi: 10.1002/cbic.201700425. Epub 2017 Sep 1.

Computation-Guided Design of a Stimulus-Responsive Multienzyme Supramolecular Assembly

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Computation-Guided Design of a Stimulus-Responsive Multienzyme Supramolecular Assembly

Lu Yang et al. Chembiochem. .

Abstract

The construction of stimulus-responsive supramolecular complexes of metabolic pathway enzymes, inspired by natural multienzyme assemblies (metabolons), provides an attractive avenue for efficient and spatiotemporally controllable one-pot biotransformations. We have constructed a phosphorylation- and optically responsive metabolon for the biodegradation of the environmental pollutant 1,2,3-trichloropropane.

Keywords: biodegradation; enzymes; photo-crosslinking; protein design; supramolecular enzyme assembly.

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