Response of human-immunodeficiency-virus-associated neurological disease to 3'-azido-3'-deoxythymidine

Lancet. 1987 Jan 17;1(8525):132-5. doi: 10.1016/s0140-6736(87)91968-4.


Four patients with human-immuno-deficiency-virus-associated neurological disease were treated with 3'-azido-3'-deoxythymidine (AZT). Three (two with chronic dementia, and one with chronic dementia and peripheral neuropathy) improved as assessed by clinical examination, psychometric tests, nerve conduction studies, and/or positron emission tomography; there was no improvement in the fourth patient who presented with paraplegia. These results support the hypothesis that certain AIDS-virus-associated neurological abnormalities are reversible by antiretroviral chemotherapy.

Publication types

  • Case Reports

MeSH terms

  • Acquired Immunodeficiency Syndrome / drug therapy*
  • Adult
  • Brain Diseases / drug therapy
  • Humans
  • Male
  • Middle Aged
  • Nervous System Diseases / drug therapy*
  • Thymidine / analogs & derivatives*
  • Thymidine / therapeutic use
  • Zidovudine


  • Zidovudine
  • Thymidine