Comparison of Edmonston-Zagreb and Schwarz strains of measles vaccine given by aerosol or subcutaneous injection

Lancet. 1987 Jan 17;1(8525):150-3. doi: 10.1016/s0140-6736(87)91978-7.

Abstract

The serological response to measles vaccine was tested in Bangladesh in groups of infants aged 4-6 months who received equal doses of Edmonston-Zagreb or Schwarz vaccine by subcutaneous injection or by aerosol. Seroconversion (as measured by the haemagglutination test) occurred in 62% of infants receiving Edmonston-Zagreb strain by injection compared with only 37% of those receiving Schwarz strain. Seroconversion occurred in 35% of those given Edmonston-Zagreb and 34% of those given Schwarz vaccine by aerosol. Edmonston-Zagreb strain appears more effective than Schwarz vaccine in this population and further studies are indicated in other populations where early measles immunisation is desirable.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aerosols
  • Antibodies, Viral / analysis
  • Bangladesh
  • Female
  • Humans
  • Infant
  • Injections, Subcutaneous
  • Measles / immunology
  • Measles Vaccine / administration & dosage*
  • Measles Vaccine / classification
  • Measles virus / immunology
  • Rural Population
  • Time Factors
  • Vaccination / methods

Substances

  • Aerosols
  • Antibodies, Viral
  • Measles Vaccine