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Review
, 139, 153-167

Tau Protein Aggregation in Alzheimer's Disease: An Attractive Target for the Development of Novel Therapeutic Agents

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Review

Tau Protein Aggregation in Alzheimer's Disease: An Attractive Target for the Development of Novel Therapeutic Agents

Marie Jouanne et al. Eur J Med Chem.

Abstract

Alzheimer's Disease (AD) is a neurodegenerative brain disorder in which many biological dysfunctions are involved. Among them, two main types of lesions were discovered and widely studied: the amyloid plaques and the neurofibrillary tangles (NFTs). These two lesions are caused by the dysfunction and the accumulation of two proteins which are, respectively, the beta-amyloid peptide and the tau protein. The process that leads these two proteins to aggregate is complex and is the subject of current studies. After a brief description of the aggregation mechanisms, we will provide an overview of new therapeutic agents targeting the different dysfunctions and toxic species found during aggregation.

Keywords: Aggregation; Alzheimer's disease; Tau protein; Therapeutic agents.

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