Malignant Pleural Mesothelioma: State of the art and advanced cell therapy

Eur J Med Chem. 2017 Dec 15;142:266-270. doi: 10.1016/j.ejmech.2017.07.063. Epub 2017 Aug 2.

Abstract

Malignant Pleural Mesothelioma (MPM) is an aggressive malignancy highly resistant to chemotherapy, with a response rate of 20% of patients and for this reason an efficient treatment is still a challenge. Platinum-based chemotherapy in association with a third-generation antifolate is the front-line standard of care whereas any second-line treatment was approved for MPM thus making it a pathology that evokes the need for new therapeutic agents. Different platinum-drugs were synthesised and tested as an option for patients who are not candidates to cisplatin-based therapy. Among these, monofunctional cationic antineoplastic platinum compounds received a special attention in the last decade. Alternative strategies to the commonly used combination-therapy resulted from the use of Mesenchymal Stromal Cells (MSC) widely used in the field of regenerative medicine and recently proposed as natural carriers for a selective delivery of chemotherapeutic agents and from the use of immune checkpoint and kinase inhibitors. The present short review shed light on the recent state of art and the future perspectives relative to MPM therapy.

Keywords: Cationic platinum complex; Cisplatin derivatives; Malignant pleural mesothelioma (MPM); Mesenchymal stromal cells (MSC); Pemetrexed.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use*
  • Cell- and Tissue-Based Therapy / methods
  • Cisplatin / administration & dosage
  • Cisplatin / analogs & derivatives
  • Cisplatin / pharmacology
  • Cisplatin / therapeutic use
  • Drug Delivery Systems / methods*
  • Humans
  • Immunotherapy / methods
  • Lung Neoplasms / pathology
  • Lung Neoplasms / therapy*
  • Mesenchymal Stem Cell Transplantation / methods*
  • Mesenchymal Stem Cells / cytology
  • Mesothelioma / pathology
  • Mesothelioma / therapy*
  • Mesothelioma, Malignant
  • Organoplatinum Compounds / administration & dosage
  • Organoplatinum Compounds / chemistry
  • Organoplatinum Compounds / pharmacology
  • Organoplatinum Compounds / therapeutic use*
  • Pemetrexed / administration & dosage
  • Pemetrexed / chemistry
  • Pemetrexed / pharmacology
  • Pemetrexed / therapeutic use
  • Pleural Neoplasms / pathology
  • Pleural Neoplasms / therapy*

Substances

  • Antineoplastic Agents
  • Organoplatinum Compounds
  • Pemetrexed
  • Cisplatin