The Ribosome Holds the RNA Polymerase on Track in Bacteria

Trends Biochem Sci. 2017 Sep;42(9):686-689. doi: 10.1016/j.tibs.2017.07.003. Epub 2017 Aug 8.


The central dogma of molecular biology comprises two fundamental mechanistic steps of gene expression (transcription and translation), which, in bacteria, are coupled. A recent study provides structural insights into a supercomplex between the RNA polymerase and the ribosome, thus highlighting the synergy between two key macromolecular machineries in the cell.

Keywords: RNA polymerase; bacteria; gene expression; ribosome; transcription; translation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Bacteria / metabolism*
  • DNA-Directed RNA Polymerases / chemistry
  • DNA-Directed RNA Polymerases / metabolism*
  • Models, Molecular
  • Ribosomes / chemistry
  • Ribosomes / metabolism*


  • DNA-Directed RNA Polymerases