Effect of oestrogen and testosterone implants on psychological disorders in the climacteric

Lancet. 1987 Feb 7;1(8528):297-9. doi: 10.1016/s0140-6736(87)92026-5.


In a double-blind trial oestradiol, oestradiol/testosterone, or placebo implants were assessed for their effects on psychological symptoms in women attending a menopause clinic. After two months, women receiving active treatment scored better than the placebo group on a self-rating scale of distress, on anxiety, and on depression (p less than 0.05). Postmenopausal but not perimenopausal women improved after placebo, and at 4 months the scores in the three groups no longer differed significantly.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Climacteric / psychology*
  • Clinical Trials as Topic
  • Depressive Disorder / drug therapy
  • Double-Blind Method
  • Drug Implants
  • Estradiol / administration & dosage
  • Estradiol / therapeutic use*
  • Female
  • Humans
  • Neurotic Disorders / drug therapy*
  • Psychological Tests
  • Testosterone / administration & dosage
  • Testosterone / therapeutic use*


  • Drug Implants
  • Testosterone
  • Estradiol