Vaccinations in the first year of life and risk of atopic disease - Results from the KiGGS study

Vaccine. 2017 Sep 12;35(38):5156-5162. doi: 10.1016/j.vaccine.2017.07.111. Epub 2017 Aug 8.


Background: The study focused on the question of whether and - if so - to what direction and extent immunisations in the 1st year may be associated with the risk of being diagnosed with atopic diseases after the 1st year of life.

Methods: Data from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS, 2003-2006) were analysed. For analyses of potential associations between vaccination status and risk of hay fever, atopic dermatitis or asthma, sample sizes of 15254, 14297, and 15262, respectively, were available.

Results: Children with a sufficient TDPHiHeP vaccination at the end of the 1st year of life had a lower risk of being diagnosed with hay fever after the 1st year of life (adjusted prevalence ratio 0.85, 95% confidence interval 0.76-0.96). Analyses for associations between TDPHiHeP vaccination and risk of atopic dermatitis or asthma, or between age at onset of vaccination or of the number of antigens vaccinated in the 1st year of life and risk of atopic disease failed to yield statistical significance.

Conclusions: Our results provide no evidence that immunisations in the 1st year of life may increase the risk of atopic disease. If any association exists at all, our results may be interpreted as weakly supportive of the hypothesis that immunisations may slightly decrease the risk of atopy in later life.

Keywords: Children; Immunisation; Paediatrics; Risk of atopic disease; Vaccination.

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Dermatitis, Atopic / immunology*
  • Dermatitis, Atopic / prevention & control*
  • Diphtheria / immunology
  • Diphtheria / prevention & control
  • Female
  • Haemophilus influenzae / immunology
  • Hepatitis B / immunology
  • Hepatitis B / prevention & control
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Poliomyelitis / immunology
  • Poliomyelitis / prevention & control
  • Vaccination*
  • Whooping Cough / immunology
  • Whooping Cough / prevention & control