Association Between Tumour Necrosis Factor in Serum and Fatal Outcome in Patients With Meningococcal Disease

Lancet. 1987 Feb 14;1(8529):355-7. doi: 10.1016/s0140-6736(87)91728-4.

Abstract

Serum samples taken on admission from 79 patients with meningococcal meningitis, septicaemia, or both, were examined in a highly sensitive bioassay for tumour necrosis factor (TNF). TNF was detected in samples from 10 of 11 patients who died but from only 8 of 68 survivors. All 5 patients with serum TNF levels over 440 units/ml (corresponding to 0.1 ng/ml recombinant TNF) died.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Child, Preschool
  • Female
  • Glycoproteins / blood*
  • Humans
  • Infant
  • Male
  • Meningitis, Meningococcal / blood
  • Meningitis, Meningococcal / mortality
  • Meningococcal Infections / blood
  • Meningococcal Infections / mortality*
  • Middle Aged
  • Tumor Necrosis Factor-alpha

Substances

  • Glycoproteins
  • Tumor Necrosis Factor-alpha