Cutaneous Malignant Vascular Neoplasms

Clin Lab Med. 2017 Sep;37(3):633-646. doi: 10.1016/j.cll.2017.06.004. Epub 2017 Jul 13.


Accurate diagnosis of cutaneous malignant vascular tumors, including angiosarcoma and epithelioid hemangioendothelioma, is critical for determination of appropriate clinical management and prognosis. Although there have been significant advances in understanding genetic aspects of cutaneous vascular biology, differential diagnosis of malignant vascular tumor involving skin and superficial soft tissue is a frequent source of difficulty. This brief overview highlights the clinicopathologic features of primary and secondary cutaneous angiosarcoma and epithelioid hemangioendothelioma and also provides a short summary of newer molecular data.

Keywords: Angiosarcoma; Atypical vascular lesion; Cutaneous vascular tumors; Epithelioid hemangioendothelioma; Molecular pathology.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / analysis
  • Diagnosis, Differential
  • Hemangioendothelioma, Epithelioid / chemistry
  • Hemangioendothelioma, Epithelioid / pathology*
  • Hemangiosarcoma / chemistry
  • Hemangiosarcoma / pathology*
  • Humans
  • Skin Neoplasms / chemistry
  • Skin Neoplasms / pathology*


  • Biomarkers, Tumor