Predictive value of multiple cytokines and chemokines for mortality in an admixed population: 15-year follow-up of the Bambui-Epigen (Brazil) cohort study of aging

Exp Gerontol. 2017 Nov;98:47-53. doi: 10.1016/j.exger.2017.08.002. Epub 2017 Aug 9.

Abstract

Inflammation, particularly elevated IL-6 serum levels, has been associated with increased mortality risk, mostly in Caucasians. The influence of genetic ethno-racial background on this association is unknown. We examined associations between baseline serum levels of Interleukin-6 (IL-6) and other cytokines (IL1-2, TNF, IL-10, and IL1β) and chemokines (CCL2, CCL5, CXCL8, CXCL9 and CXCL10) with 15-year mortality in 1,191 admixed Brazilians aged 60years and over. Elevated IL6 level (but not other biomarkers) was associated with increased risk of deaths with fully adjusted hazard ratios of 1.51 (95% CI=1.15, 1.97), 1.54 (95% CI=1.20, 1.96) and 1.79 (95% CI=1.40, 2.29) for the 2nd, 3rd and the highest quartiles, respectively. Genomic African and Native American proportions did not modify the association (p>0.05). The discriminatory ability to predict death of a model based on IL-6 alone was similar as that of a comprehensive morbidity score (C statistics=0.59 and 0.60, respectively). The abilities of IL-6 and the morbidity score models to predict death remained stable for very long term after the baseline measurement. Our results indicate that genome-based African and Native American ancestries have no impact on the prognostic value of IL-6 for mortality.

Keywords: Admixed population; Chemokines; Cytokines; Genomic ancestry; Inflammatory markers; Interleukin-6; Mortality.

Publication types

  • Comparative Study

MeSH terms

  • African Continental Ancestry Group / genetics
  • Aged
  • Aged, 80 and over
  • Aging / blood*
  • Aging / ethnology
  • Aging / genetics
  • Biomarkers / blood
  • Brazil / epidemiology
  • Cause of Death
  • Chemokine CCL5 / blood
  • Chemokine CXCL9 / blood
  • Chemokines / blood*
  • Female
  • Follow-Up Studies
  • Humans
  • Indians, North American / genetics
  • Interleukin-6 / blood*
  • Interleukin-8 / blood
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Prognosis
  • Proportional Hazards Models
  • Risk Assessment
  • Risk Factors
  • Time Factors

Substances

  • Biomarkers
  • CCL5 protein, human
  • CXCL8 protein, human
  • CXCL9 protein, human
  • Chemokine CCL5
  • Chemokine CXCL9
  • Chemokines
  • IL6 protein, human
  • Interleukin-6
  • Interleukin-8