Metastatic Cardiac Angiosarcoma to the Lung, Spine, and Brain: A Case Report and Review of the Literature

World Neurosurg. 2017 Nov:107:1049.e9-1049.e12. doi: 10.1016/j.wneu.2017.08.023. Epub 2017 Aug 9.


Background: Metastatic angiosarcoma to the brain is a rare entity without an established management protocol.

Case description: A man with primary cardiac angiosarcoma presented with a rare brain metastasis. The patient underwent successful resection of the brain metastasis and was initiated on chemotherapy only for his systemic disease. The patient did not develop local recurrence. A review of primary and metastatic central nervous system angiosarcoma, its pathologic features, clinical disease course, treatment strategies, and genomics is also provided.

Conclusions: Angiosarcomas are rare tumors that are difficult to treat. Gross total resection of a central nervous system metastasis is recommended before initiation of adjuvant chemotherapy or radiation therapy. Close follow-up is still required given the propensity for continued metastasis of these tumors. Future treatments may be developed based on the genomics of angiosarcomas.

Keywords: Angiosarcoma; Brain metastasis; Chemotherapy.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Brain Neoplasms / diagnostic imaging*
  • Brain Neoplasms / secondary
  • Heart Neoplasms / diagnostic imaging*
  • Heart Neoplasms / surgery
  • Hemangiosarcoma / diagnostic imaging*
  • Hemangiosarcoma / surgery
  • Humans
  • Lung Neoplasms / diagnostic imaging*
  • Lung Neoplasms / secondary
  • Male
  • Middle Aged
  • Spinal Neoplasms / diagnostic imaging*
  • Spinal Neoplasms / secondary