Immuno-Oncology Integrative Networks: Elucidating the Influences of Osteosarcoma Phenotypes
- PMID: 28804242
- PMCID: PMC5533255
- DOI: 10.1177/1176935117721691
Immuno-Oncology Integrative Networks: Elucidating the Influences of Osteosarcoma Phenotypes
Abstract
In vivo and in vitro functional phenotyping characterization was recently obtained with reference to an experimental pan-cancer study of 22 osteosarcoma (OS) cell lines. Here, differentially expressed gene (DEG) profiles were recomputed from the publicly available data to conduct network inference on the immune system regulatory activity across the characterized OS phenotypes. Based on such DEG profiles, and for each phenotype that was analyzed, we obtained coexpression networks and bio-annotations for them. Then, we described the immune-modulated influences in phenotype-specific networks' integrating pathway, transcription factor, and microRNA regulations. Overall, this approach seems suitable for representing heterogeneity in OS tumorigenesis.
Keywords: Osteosarcoma; immune-mediated regulation; networks; phenotypes.
Conflict of interest statement
Declaration of Conflicting Interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Figures
Similar articles
-
How microRNA and transcription factor co-regulatory networks affect osteosarcoma cell proliferation.PLoS Comput Biol. 2013;9(8):e1003210. doi: 10.1371/journal.pcbi.1003210. Epub 2013 Aug 29. PLoS Comput Biol. 2013. PMID: 24009496 Free PMC article.
-
Multitype Network-Guided Target Controllability in Phenotypically Characterized Osteosarcoma: Role of Tumor Microenvironment.Front Immunol. 2017 Jul 31;8:918. doi: 10.3389/fimmu.2017.00918. eCollection 2017. Front Immunol. 2017. PMID: 28824643 Free PMC article.
-
Exploring the molecular mechanisms of osteosarcoma by the integrated analysis of mRNAs and miRNA microarrays.Int J Mol Med. 2018 Jul;42(1):21-30. doi: 10.3892/ijmm.2018.3594. Epub 2018 Mar 27. Int J Mol Med. 2018. PMID: 29620143 Free PMC article.
-
Functional characterisation of osteosarcoma cell lines and identification of mRNAs and miRNAs associated with aggressive cancer phenotypes.Br J Cancer. 2013 Oct 15;109(8):2228-36. doi: 10.1038/bjc.2013.549. Epub 2013 Sep 24. Br J Cancer. 2013. PMID: 24064976 Free PMC article.
-
Screening of disorders associated with osteosarcoma by integrated network analysis.Biosci Rep. 2019 May 21;39(5):BSR20190235. doi: 10.1042/BSR20190235. Print 2019 May 31. Biosci Rep. 2019. PMID: 30936265 Free PMC article.
Cited by
-
Osteosarcoma in a Teenage Athlete With a Swollen Knee Joint.Cureus. 2024 Mar 18;16(3):e56366. doi: 10.7759/cureus.56366. eCollection 2024 Mar. Cureus. 2024. PMID: 38633972 Free PMC article.
-
Expression of E-cadherin and N-cadherin in Epithelial-to-Mesenchymal Transition of Osteosarcoma: A Systematic Review.Cureus. 2023 Nov 27;15(11):e49521. doi: 10.7759/cureus.49521. eCollection 2023 Nov. Cureus. 2023. PMID: 38156135 Free PMC article. Review.
References
-
- Melero I, Berman DM, Aznar MA, Korman AJ, Pérez Gracia JL, Haanen J. Evolving synergistic combinations of targeted immunotherapies to combat cancer. Nat Rev Cancer. 2015;15:457–472. - PubMed
-
- Adams JL, Smothers J, Srinivasan R, Hoos A. Big opportunities for small molecules in immuno-oncology. Nat Rev Drug Discov. 2015;14:603–622. - PubMed
-
- Prahallad A, Bernards R. Opportunities and challenges provided by crosstalk between signalling pathways in cancer. Oncogene. 2016;35:1073–1079. - PubMed
-
- Collins M, Wilhelm M, Conyers R, et al. Benefits and adverse events in younger versus older patients receiving neoadjuvant chemotherapy for osteosarcoma: findings from a meta-analysis. J Clin Oncol. 2013;31:2303–2312. - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources
