Epigenetics and DNA Methylomic Profiling in Alzheimer's Disease and Other Neurodegenerative Diseases

J Neurochem. 2017 Oct;143(2):158-170. doi: 10.1111/jnc.14148. Epub 2017 Sep 21.

Abstract

Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of various neurodegenerative diseases. In this review, we discuss advances that have been made toward understanding the role of epigenetic processes in neurodegenerative disorders, with a particular focus on Alzheimer's disease, where the most extensive studies have been undertaken to date. We provide a brief overview of DNA modifications, followed by a summarization of studies of DNA modifications in Alzheimer's disease and other neurodegenerative diseases.

Keywords: Alzheimer's disease; DNA hydroxymethylation; DNA methylation; epigenetic; epigenome-wide association study; genetic.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / genetics*
  • Alzheimer Disease / metabolism*
  • Animals
  • DNA Methylation / physiology*
  • Epigenesis, Genetic / physiology*
  • Gene Expression Profiling
  • Humans
  • Neurodegenerative Diseases / genetics
  • Neurodegenerative Diseases / metabolism