Abstract
JC polyomavirus (JCPyV)-associated nephropathy (JCPyVAN) occurs in <3% of PVAN cases after renal transplantation. We report the first confirmed case to our knowledge of JCPyVAN diagnosed by kidney biopsy in the early 6 months post transplant in Thailand. In this case report, recovery of renal allograft function was not observed after reduction of immunosuppressive agents and administration of intravenous immunoglobulin and cidofovir. Despite persistent JCPyV viruria, no significant further decline in allograft function was documented at 15 months post transplant.
Keywords:
JC virus nephropathy; allograft dysfunction; kidney transplant.
© 2017 The Authors. Transplant Infectious Disease Published by John Wiley & Sons Ltd.
MeSH terms
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Adult
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Allografts / pathology
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Allografts / virology*
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Biopsy
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Creatinine / blood
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Graft Rejection / prevention & control
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Humans
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Immunoglobulins, Intravenous / therapeutic use
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Immunosuppressive Agents / adverse effects
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JC Virus / isolation & purification*
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Kidney / pathology
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Kidney / virology*
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Kidney Diseases / blood
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Kidney Diseases / drug therapy
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Kidney Diseases / urine
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Kidney Diseases / virology*
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Kidney Failure, Chronic / surgery
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Kidney Transplantation / adverse effects*
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Male
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Polyomavirus Infections / blood
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Polyomavirus Infections / drug therapy
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Polyomavirus Infections / urine
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Polyomavirus Infections / virology
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Postoperative Complications / blood
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Postoperative Complications / drug therapy
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Postoperative Complications / urine
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Postoperative Complications / virology*
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Time Factors
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Tumor Virus Infections / blood
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Tumor Virus Infections / drug therapy
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Tumor Virus Infections / urine
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Tumor Virus Infections / virology
Substances
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Immunoglobulins, Intravenous
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Immunosuppressive Agents
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Creatinine