Nicotine cue in rats: effects of central administration of ganglion-blocking drugs

Br J Pharmacol. 1987 Jan;90(1):239-46. doi: 10.1111/j.1476-5381.1987.tb16845.x.


In rats trained to discriminate nicotine from saline, a single intraventricular injection of a small dose of the quaternary ganglion-blocking drug chlorisondamine blocked the response to nicotine for four weeks. pentolinium was only weakly active and hexamethonium was inactive as a nicotine antagonist under the conditions used, even in doses that were just below those producing myoclonic jerks. Chlorisondamine had no blocking effect in rats trained to discriminate the non-nicotinic drugs midazolam or morphine from saline. Intraventricular injections of chlorisondamine have a specific and unusually persistent nicotine-blocking action, the mechanism of which requires further investigation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chlorisondamine / pharmacology*
  • Cues
  • Discrimination Learning / drug effects*
  • Drug Interactions
  • Hexamethonium
  • Hexamethonium Compounds / pharmacology
  • Injections, Intraventricular
  • Male
  • Midazolam / pharmacology
  • Morphine / pharmacology
  • Nicotine / antagonists & inhibitors*
  • Pentolinium Tartrate / pharmacology
  • Rats


  • Hexamethonium Compounds
  • Hexamethonium
  • Nicotine
  • Morphine
  • Pentolinium Tartrate
  • Chlorisondamine
  • Midazolam