Orbital Hemangiopericytoma in 68Ga-Prostate-Specific Membrane Antigen-HBED-CC PET/CT

Clin Nucl Med. 2017 Oct;42(10):812-814. doi: 10.1097/RLU.0000000000001791.


A 76-year-old man with biochemical relapse of prostate cancer underwent Ga-prostate-specific membrane antigen PET/CT. Besides a local lymph node metastasis, a nodular structure inside the left orbit caudal to the optic nerve showed increased uptake. A metastasis in this location is unlikely. The subsequently performed MRI showed the structure being T1 hypointense, T2 indifferent, and strongly gadolinium contrast agent enhancing. Histopathologic examination after surgical removal identified the tumor as hemangiopericytoma, which rarely occurs in the orbit. Regarding the intense uptake observed, prostate-specific membrane antigen-targeting PET tracers could bear potential for staging purposes of this tumor entity.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antigens, Surface / metabolism*
  • Edetic Acid / analogs & derivatives*
  • Edetic Acid / metabolism
  • Glutamate Carboxypeptidase II / metabolism*
  • Hemangiopericytoma / diagnostic imaging*
  • Hemangiopericytoma / metabolism
  • Humans
  • Male
  • Orbital Neoplasms / diagnostic imaging*
  • Orbital Neoplasms / metabolism
  • Positron Emission Tomography Computed Tomography*


  • Antigens, Surface
  • N,N'-bis(2-hydroxy-5-(ethylene-beta-carboxy)benzyl)ethylenediamine N,N'-diacetic acid
  • Edetic Acid
  • FOLH1 protein, human
  • Glutamate Carboxypeptidase II