Pacinian Corpuscles in Human Lymph Nodes

Anat Rec (Hoboken). 2017 Dec;300(12):2233-2238. doi: 10.1002/ar.23679. Epub 2017 Aug 18.


The occurrence of Pacinian corpuscles associated to lymph nodes is an anatomical rarity and very scarce information exists in this regard. Here we examined immunohistochemically four Pacinian corpuscles found in the close vicinity of the hiliar blood vessels of lymph nodes (2 cervical, 1 axillary, and 1 inguinal) during routine surgical pathology. Pacinian corpuscles were normally arranged and displayed a pattern of protein distribution as follows: the axon was positive for neurofilament proteins and neuron specific enolase, the inner core cells showed intense S100 protein and vimentin immunostaining while they were negative for glial fibrillary acidic protein, type IV collagen and glucose transporter 1; vimentin, type IV collagen, and glucose transporter 1 were also observed also in the outer-core and the capsule. These results are in agreement with those reported for cutaneous Pacinian corpuscles, demonstrating that the immunohistochemical profile of these corpuscles is independent of its anatomical localization. The possible functional significance of Pacinian corpuscles in lymph nodes is discussed. Anat Rec, 300:2233-2238, 2017. © 2017 Wiley Periodicals, Inc.

Keywords: Pacinian corpuscles; human; immunohistochemical profile; lymph nodes.

Publication types

  • Case Reports

MeSH terms

  • Acquired Immunodeficiency Syndrome / diagnosis
  • Acquired Immunodeficiency Syndrome / surgery
  • Aged
  • Aged, 80 and over
  • Hernia, Inguinal / diagnosis
  • Hernia, Inguinal / surgery
  • Humans
  • Lymph Nodes / pathology*
  • Lymph Nodes / surgery*
  • Middle Aged
  • Neoplasms / diagnosis
  • Neoplasms / surgery
  • Pacinian Corpuscles / pathology*
  • Pacinian Corpuscles / surgery*