Association between PARK16 and Parkinson's disease: A meta-analysis

Neurosci Lett. 2017 Sep 14;657:179-188. doi: 10.1016/j.neulet.2017.08.022. Epub 2017 Aug 12.

Abstract

Recent years, several case-control studies reported that two polymorphisms (rs947211 and 1572913) within the PARK16 locus were associated with the Parkinson's disease (PD). However, the results were still controversial. Herein, we conducted a comprehensive meta-analysis to estimate the associations between two polymorphisms and PD. Seven databases (PubMed, Google Scholar, EMBASE, Web of Science, CNKI (China National Knowledge Infrastructure), VIP and Wanfang) were searched to identify the eligible studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the associations of two polymorphisms with PD susceptibility. Totally, 15 studies with 6637 cases and 6774 controls were included in our meta-analysis. The results showed that rs947211 variants were associated with a decreased risk of PD in overall population. Stratified analysis found that rs947211 variants were associated with a significantly decreased risk of PD in Northeast Asian population, but a slightly decreased risk of PD in Southeast Asian and Caucasian population. With regard to rs1572913 polymorphism, the results suggested that rs1572913 variants contribute to decrease the risk of PD. Therefore, our meta-analysis suggested that rs947211 variants (A allele, AG and GG genotypes) may decrease the risk of PD in overall population, particularly in Northeast Asian population; and T allele, TC and TT genotypes of rs1572913 variants contributed to decrease the risk of PD.

Keywords: LRRK2; Meta-analysis; PARK16; Parkinson’s disease; RAB7L1.

Publication types

  • Meta-Analysis

MeSH terms

  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Parkinson Disease / genetics*
  • rab GTP-Binding Proteins
  • rab1 GTP-Binding Proteins / genetics*

Substances

  • Rab29 protein, human
  • rab GTP-Binding Proteins
  • rab1 GTP-Binding Proteins