Covalent modification of biological targets with natural products through Paal-Knorr pyrrole formation

Nat Prod Rep. 2017 Aug 30;34(9):1051-1060. doi: 10.1039/c7np00024c.

Abstract

Covering: up to June 2017Natural products and endogenous metabolites engage specific targets within tissues and cells through complex mechanisms. This review examines the extent to which natural systems have adopted the Paal-Knorr reaction to engage nucleophilic amine groups within biological targets. Current understanding of this mode of reactivity is limited by only a few examples of this reaction in a biological context. This highlight is intended to stimulate the scientific community to identify potential research directions and applications of the Paal-Knorr reaction in native and engineered biological systems.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Biological Products / chemistry*
  • Molecular Structure
  • Pyrroles / chemical synthesis*
  • Pyrroles / chemistry

Substances

  • Biological Products
  • Pyrroles