Zebrafish earns its stripes for in vivo ASC speck dynamics

J Cell Biol. 2017 Sep 4;216(9):2615-2618. doi: 10.1083/jcb.201708002. Epub 2017 Aug 15.


Assembly of the ASC speck is critical for signaling by the inflammasome. In this issue, Kuri et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201703103) use live microscopy to track fluorescently tagged endogenous ASC in the zebrafish, describing the molecular domains driving ASC speck assembly and identifying a key role for macrophages in ASC speck removal in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cytoskeletal Proteins*
  • Inflammasomes
  • Macrophages
  • Signal Transduction
  • Zebrafish*


  • Cytoskeletal Proteins
  • Inflammasomes